Sodium taurolithocholate ( —— )

产品货号. M19644 CAS No. 6042-32-6

COA

Datasheet

HNMR

HPLC

MSDS

Handing Instructions

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产品名称

Sodium taurolithocholate
注意事项

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
产品简述

主要人类代谢物，一种胆汁酸，可抑制放射性配体与毒蕈碱 M1 受体的结合，但不与 M2 或 M3 受体结合。
产品描述

The major human metabolite a bile acid which inhibits radioligand binding to muscarinic M1 but not to M2 or M3 receptors.
体外实验

Taurolithocholic acid (TLCA) at low concentrations (5 μM) tends to selectively increase the membrane-associated fraction of the e-isoform of PKC by 44.1% ± 40.2%.TLCA (10 μM) selectively induces translocation of theε-isoform of PKC to the hepatocellular membranes, a key step for activation of mobile PKC isoforms.
体内实验

Taurolithocholic acid (TLCA) exerts cholestatic effects via PI3K-dependent mechanisms in perfused rat Livers and rat hepatocyte couplets.
同义词

——
通路

Others
靶点

Other Targets
受体

Others
研究领域

——
适应症

——

CAS Number

6042-32-6
分子量

505.69
分子式

C26H44NNaO5S
纯度

>98% (HPLC)
溶解度

DMSO: 20 mg/mL
SMILES

[Na+].C[C@H](CCC(=O)NCCS([O-])(=O)=O)[C@H]1CC[C@H]2[C@@H]3CC[C@@H]4C[C@H](O)CC[C@]4(C)[C@H]3CC[C@]12C
化学全称

——

1.Ha C E Petersen C E Park D S et al. Investigations of the effects of ethanol on warfarin binding to human serum albumin[J]. 2000 7(2):114-121.

计算器

产品手册

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